This I Believe Essay Example | Topics and Well Written Essays - 1250 words

This I Believe - Essay Example The managers of the organization must cultivate proper understanding of the science of ergonomics. (Placement of proper men at the proper jobs) Efforts for individual perfection will lead to societal prosperity. Ongoing assessment and remedial measure are necessary for an organization to remain at the top and win the appreciation. When it is necessary to change, the organizational culture must change in keeping with the requirements of time, but when it is not necessary to change, it is necessary not to change. For short terms gains, long term vision of the organization must never be sacrificed. Enhance the merits of the culture, without causing damage to the soul of the organization. This I Believe! This I put into practice! Richard S. Gallagher argues, â€Å"In an organizational setting, the meaning of culture extends to the core beliefs, behaviors, and actions behind its daily business life†¦its values are unspoken, but they exert a powerful influence on the behavior of thos e who choose to be part of that organization.†(4) My organization attaches great importance to ethical and socio-spiritual values that are beneficial for the humankind. The communication received on that misty Monday of the winter stunned us. â€Å"Yours is one of the five organizations shortlisted for the grant. Our Senior Vice-President will visit your Head Office this Friday. He will conduct the final interview and ask you four questions. The duration of the interview is ten minutes and any one nominee from the list of your Managing Committee Members will appear for the interview. â€Å"Incredible! The fate of one time grant of $80,000 will be decided within ten minutes! That too on the basis of 4 questions! An urgent meeting of the 8 Managing Committee Members is convened the same evening and discussion on the startling communication begins. We work for the cause reformation and rehabilitation of the visually challenged persons, and education for the slum children. We ar e in this field for the last two decades. Education to the slum children is free; they are also provided books and clothing, mid-day meals, transportation from their residence to school etc. As for the visually challenged, cottage industry units like manufacturing candle, biscuits etc. have been established and they are given salary as per the government norms. The profits earned are ploughed back to create more employment opportunities for the visually challenged. Not one of the 200 persons doing service on the administrative side, and the teaching staff are compensated monetarily. All of them work on honorary basis, with a mission and not for commission! After prolonged discussion, the onus of facing the interview falls to my lot. I begin preparations for the interview with right earnest and study the past history of the organization from the day of its inception when it is managed by just 4 volunteers. I go through the balance sheets, year-wise achievements, the salient features of the present structures, etc. I do an extensive study of the problems of the visually challenged, their international significance, role of the United Nations Agencies, statistics related to important countries, outstanding achievements of some of the visually challenged, the issues related to slum children etc. My level of preparations in those four days is that of a candidate appearing for the highest Civil Service Examination! My organization must get this grant! How will I face the other Managing Committee Members if we fail to get this grant! †¦..and Friday arrives! Sharp at 9.45 a.m. Mr. James Patterson, the Vice-President of Charity Select Organization arrives with his Secretary. We escort him to the Conference Room of the two-story structure, which is our Head Office. I welcome him with a

See the order instructions Essay Example | Topics and Well Written Essays - 250 words

See the order instructions - Essay Example The overall gothic theme as presented in the movie is about a women Emily who receives a great deal of fortune as her father dies. Emily did not have the right to select the husband for herself because she was wealthy and needed to marry someone who is worth it. As a result, she murders the man she loved and ultimately presents a gothic element (Danticat). Where Are You Going, Where Have You Been by Joyce Carol Oates is binded by the suspence through myster as a gothic element. This is prevalent throughout the story leaving the readers as astonished. Finally, New York Day Woman? by Edwidge Danticat is amazingly written gothic story which is not just limited to suspense and mystery but it includes horrific species through realism as a pattern (Danticat). The common factors among all these three chosen texts for the paper were the degree of intensity of mystery, suspense and growth of the character as a complex one. The elements have rather been chosen to help the readers to enjoy the gothic genre of

Factors in Biochemical Toxicology

Factors in Biochemical Toxicology Tambudzai Phiri Ndashe Maha Farid In the lecture we discussed several responses of the lung to acute injuries. List these responses and discuss one of these responses providing an example of a toxin or a chemical that induces such response in the lung. (5 points) The lung is particularly vulnerable to toxicity because it gets exposed to foreign compounds both in the external environment and internally through the bloodstream. Acute responses of the lung to injury occur in order to protect the lung from further damage. These responses include the following: Irritation following exposure to volatile gases such as ammonia and chlorine may cause bronchitis and changes in permeability. Exposure to gases or irritants may also lead to damage of the epithelial lining of the entire respiratory tract. Irritation of nerve endings in the respiratory epithelium may occur following exposure to gases or irritants to protect from further exposure. Xenobiotic metabolizing enzymes such as Glutathione S-transferase in the lung tissue also play a role in the pathogenesis of pulmonary toxic response. Oxidative burden following exposure to gases such as ozone, nitrogen dioxide or tobacco smoke. Airway reactivity and bronchoconstriction may occur on exposure to nitric oxides, cholinergic drugs, histamine and tobacco smoke. Pulmonary edema may occur as result of high concentrations of acrolein, hydrogen chloride, nitrogen dioxide, ammonia or phosgene. Pulmonary edema Pulmonary edema is the accumulation of fluid in the lung, which collects in the alveoli; it leads to impaired gas exchange and may cause respiratory failure (Medical News Today, 2014). Exposure to ammonia, a volatile and water soluble gas, has been associated with pulmonary edema. The ammonia gets absorbed into the aqueous secretions of the upper airways of the respiratory system, it reacts with the water in aqueous secretions to from ammonium hydroxide, an alkaline and corrosive solution. Though ammonia may not cause permanent damage it leads to impaired permeability and the accumulation of fluid which obstructs the upper airway and collects in the air sacs. This may lead to low blood oxygen content and altered mental status (Center for Disease Control and Prevention, 2014). The dissolving of the ammonia into aqueous solutions on mucous membranes may also result in corrosive injury to the mucus membranes. High concentrations of acrolein, a common component of smoke, can also cause p ulmonary edema following smoke inhalation. Paraquat, is a widely used herbicide that specifically exerts its toxic effect on the lung tissue. Discuss the mechanism of toxicity of paraquat explaining the specificity of lung toxicity induced by this compound. (5 points) Paraquat has been implicated in number of both accidental and intentional cases of poisoning. It causes dose-dependent toxic effects following oral ingestion; and, absorption of a toxic dose usually results in abdominal pain, vomiting and diarrhea. In addition to the lung, other target organs include mainly the kidneys, but may also cause cardiac and liver toxicity if one if exposed to large doses. Mechanism of paraquat toxicity on the lung Paraquat is selectively taken up into type I and II alveolar epithelial cells by active transport, as a result it reaches a higher concentration than in most other tissue. It causes severe lung injury and fibrosis. The mechanism of toxicity involves the initial reaction of paraquat with an electron donor such as NADPH; paraquat accepts the electron to form a stable radical cation (Figure 1); if this occurs under aerobic conditions, this electron is transferred too oxygen giving rise to superoxide; this process gets repeated over and over in the lungs due to the ready supply of oxygen, resulting in the formation of a redox cycle. The formation of the redox cycle is believed to be responsible for the toxicity by causing the following effects: the formation of large amounts of superoxide may overwhelm the neutralizing effects of superoxide dismutase, allowing the superoxide to accumulate, causing a variety of toxic effects such as the peroxidation of lipids leading to the formation of l ipid radicals that may cause membrane damage (Figure 2); and, the depletion of NADPH due to the formation of active oxygen species may compromise the alveolar cells, reducing their ability to carry out their functions. Figure 1: paraquat reduction-oxidation. Figure 2: the proposed mechanism of paraquat toxicity. Figure 1: adapted from http://www.inchem.org/documents/jmpr/jmpmono/v086pr05.gif Figure 2: adapted from http://totalpict.com/imagesb/1818/1818064104502cc34b8ffb7.gif References Timbrell, J.A. (2009). Principles of Biochemical Toxicology, 4th Edition. CRC Press. Pages 204- 205; and, 337-339. Medical News Today (2014, September 15). What is pulmonary edema? What causes pulmonary edema?  Retrieved from: http://www.medicalnewstoday.com/articles/167533.php The Center for Disease Control and Prevention (2014). Medical Management Guidelines for Ammonia. Retrieved from: http://www.atsdr.cdc.gov/MMG/MMG.asp?id=7tid=2 Maha Farid Discuss the patterns of neurotoxicity and provide one example of a toxin producing each pattern. Examples from the assigned textbooks are recommended. (6 points) The nervous system is a highly complex network of specialized cells and damage to this system may have permanent and serious effects because there is very low capacity to regenerate and little reserve functional capacity. The following are the patterns of neurotoxicity: Neuronopathy: this is the result of the destruction of the peripheral nervous system, or simply put, death of the entire neuron. The drug contaminant 1-mehtyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes specific damage to the substantia nigra area of the brain (Timbrell, 2009). It is highly lipophilic and readily enters the brain where it is readily metabolized to a toxic metabolite that is taken up by dopamine neurons. Methyl mercury also causes Neuronopathy. Axonopathy: this is the degeneration of the axon. Carbon disulfide exposure is a good example of a neurotoxin. Exposure to this solvent usually occurs in industry and causes neuronal damage in the central and peripheral nervous systems. The mechanism is believed to involve the chelation of metal ions essential for enzyme activity by the oxothiazolidine and dithiocarbamate metabolites of carbon disulfide, which result from reaction with glycine and glutathione (GSH) (Timbrell, 2009). Myelinopathy: this is a general term used to describe damage to or disorder of the myelin of peripheral nerve fibers, the myelin sheath or the white matter of the brain, in contrast to that affecting the axons (Axonopathy). A number of substances cause Myelinopathy in both the Schwann cells and the Oligodendrocytes. Lead is a good example of a neurotoxin that causes Myelinopathy, especially in children. Transmission toxicity: this is the disruption of neurotransmission. Organophosphorus pesticides such as malathion, which is used in the treatment of head lice in humans, and parathion, are good examples of neurotoxins that cause transmission toxicity. Exposure is usually accidental, suicidal or associated with homicide; and occurs via the gastrointestinal tract, the skin and the lungs. They are acetylcholinesterase inhibitors and acute toxicity manifests via the overstimulation of the muscarinic and nicotinic acetylcholine receptors. Nicotinic signs and symptoms result from the accumulation of acetylcholine at motor nerve endings in skeletal muscles and automated ganglia. This results in fatigue, involuntary twitching and even muscle weakness which may affect muscles of respiration. Death may occur from respiratory distress partly due to neuromuscular paralysis, central depression and even bronchoconstriction (Timbrell, 2009). Discuss the vulnerability of the nervous system to toxicity. (4 points) There are multiple characteristics of the nervous system that make it vulnerable to toxicity; in fact the nervous system is highly susceptible to changes in its environment. The characteristics of the nervous system that make it vulnerable to toxicity include the following: Neurons can have very long axons, making them more vulnerable to toxicity. The nervous system is also highly dependent on glucose, which is the sole source of energy to the central nervous system. This high dependence on glucose is demonstrated through fatal irreparable damage to the nervous system, even in brief obstruction of blood flow to the central nervous system. Energy shortage to the nervous system can lead to glutamate leakage which can cause severe brain injury. The long axons and large cell volume in the nervous system require high metabolic activity due to the electrical transmission of action potential and chemical transmission in the nervous system. Proper axonal transport is very essential for normal brain function. There are multiple fast and slow, anterograde and retrograde transport systems that exist in the nervous system, which complicate the process and add to the sensitivity of this area. Reference Timbrell, J.A. (2009). Principles of Biochemical Toxicology, 4th Edition. CRC Press. Pages 206; and, 339-346.

Essay --

CHAPTER NO 5 Adjustments & maintenance 5.1 Capillary Tube 5.2 Priming 5.3 Pressure Gauge Fitting 5.4 Relief Valve 5.5 Pressure Adjustment 5.6 PD Pump System Flow Diagram 5.7 External Relief Valve Adjustment 5.8 Internal Relief Valve Adjustment 5.9 Motor Lubrication 5.1 Capillary Tube:- A capillary tube is a narrow, long tube of constant diameter. In refrigeration application of capillary tube, the surface tension is not important. Tube length limit from 1.0 m to 6 m and the diameters of refrigerant capillary tubes limit from 0.5 mm to 3 mm. Due to the following two factors the pressure reduction in a capillary tube occurs: The frictional resistance offered by tube walls refrigerant has to overcome. Than that of the liquid the density of vapor is less. As it flows in the tube the average density of refrigerant decreases. The increase in acceleration or velocity of the refrigerant requires pressure drop. 5.2 Priming:- Liquid pumps can lose prime and to get the pump started this will require the pump to be primed by adding liquid to the pump and inlet pipes. Loss of "prime" ...

Investing and Financing Activities of Wendy’s

During the year of 2012, cash used for investing activities of Wendy’s totaled $189 million, increased $131 million from 2011. The two largest investing activities appeared in Wendy’s statement of cash flow are capital expenditures and acquisitions. Cash capital expenditures of Wendy’s in 2012 totaling $197. 6 million, including $71. 9 million for reimaged and new Image Activation restaurants, $13. 5 million for new restaurants, $28. 0 million for point-of-sale equipment, $23. 2 million for the construction of a new building at its corporate headquarters and $61. million for various capital projects. In the middle of 2012, Wendy’s acquired 54 franchised restaurants. The purchase price was $38. 1 million in cash. Wendy’s also agreed to lease the real estate, buildings and improvements related to some of the acquired restaurants which were considered part of the purchase transaction. Wendy’s did not incur any material acquisition-related costs. Some other important investing activities involved the investment in limited partnerships of indirect 18. 5% interest in Arby’s Restaurant Group, Inc. and approximately 11% cost method investment in Jurlique International Pty Ltd. On February 2, 2012, Wendy’s completed the sale of its investment in Jurlique and received proceeds of $27. 4 million. Wendy’s did this because prior to 2009, Wendy’s had determined that all of its remaining $8. 5 million investment in Jurlique was impaired. Wendy’s realized that Jurlique cannot help them make profit and decided to sell all of investment in Jurlique to protect stockholders equity. In the meantime, Wendy’s can use this money to strength their capital expenditures.The increase in cash used for investing activities is mainly because of the sale of Arby’s in 2011. Wendy’s sold Arby’s for $130. 0 million in cash and indirectly retained an 18. 5% interest in Arby’s and during 2012, Wendy’s received a $4. 6 million dividend from the investment in Arby’s. Wendy’s decided to sell Arby’s because Arby’s has been a weaker performer than Wendy’s in recent years after Wendy’s and Arby’s were merged in 2008. We deem it wise to sell Aryb’s because Wendy’s no longer need to worry about the poor performance of Arby’s but can earn the dividend.On the other hand, cash used for investing activities of McDonald’s totaled $3. 2 billion in 2012, increased $596 million. The increase primarily reflected higher capital expenditures and lower proceeds from sales of restaurant businesses. During the year of 2012, the two largest investing activities appeared in the statement of cash flow of McDonald’s are capital expenditures and sales of restaurant business and property. The two most important financing activities for Wendy’s are the proceeds from long-term debt and the repaymen ts of long-term debt.On May 15, 2012, Wendy’s entered into a Credit Agreement including a senior secured term loan facility of $1,125. 0 million, of which net proceeds was $1,113. 8 million with draws on May 15, 2012 and July 16, 2012. Proceeds from the 2012 Term Loan were used to repay the outstanding amounts under the 2010 Term Loan of $467. 8 million, to redeem and purchase the outstanding Senior Notes of $565. 0 million and to pay substantially all of the Credit Agreement fees and expenses. The outflow of 2012 Term Loan constituted the second largest financing activity, the repayments of long-term debt.In these two activities, we can find out that Wendy uses almost 85% of the 2012 loan to reimburse its previous debt, which shows us that the company does not have enough debt-paying ability. A good company who has the ability to make profit to repay previous debt and make another investing is what all stockholders want to see, not using new loan to redeem old loan. In concl usion, we do not agree Wendy’s using these financing activities. They should improve their operation activities to increase profit.

Critical Period and Language Acquisition Essay

Part of the reason why Genie’s case fascinated psychologists and linguists so deeply was that it presented a unique opportunity to study a hotly contested debate about language development. Nativists believe that the capacity for language is innate, while empiricists suggest that it is environmental variables that play a key role. Essentially, it boils down to the age-old nature versus nurture debate. Do genetics or environment play a greater role in the development of language? Nativist Noam Chomsky suggested that the acquisition of language could not be fully explained by learning alone. Instead, he proposed that children are born with a language acquisition device (LAD), an innate ability to understand the principles of language. Once exposed to language, the LAD allows children to learn the language at a remarkable pace. Linguist Eric Lenneberg suggests that like many other human behaviors, the ability to acquire language is subject to what are known as critical periods. A critical period is a limited span of time during which an organism is sensitive to external stimuli and capable of acquiring certain skills. According to Lenneberg, the critical period for language acquisition lasts until around age 12. After the onset of puberty, he argued, the organization of the brain becomes set and no longer able to learn and utilize language in a fully functional manner. Genie’s case presented researchers with a unique opportunity. If given an enriched learning environment, could she overcome her deprived childhood and learn language even though she had missed the critical period? If she could, it would suggest that the critical period hypothesis of language development was wrong. If she could not, it would indicate that Lenneberg’s theory was correct. Genie’s Language Progress Despite scoring at the level of a one-year-old upon her initial assessment, Genie quickly began adding new words to her vocabulary. She started by learning single words and eventually began putting two words together much the way young children do. Curtiss began to feel that Genie would be fully capable of acquiring language. After a year of treatment, she even started putting three words together occasionally. In children going through normal language development, this stage is followed by what is known as a language explosion. Children rapidly acquire new words and begin putting them together in novel ways. Unfortunately, this never happened for Genie. Her language abilities remained stuck at this stage and she appeared unable to apply grammatical rules and use language in a meaningful way. At this point, her progress leveled off and her acquisition of new language halted. While Genie was able to learn some language after puberty, her inability to use grammar (which Chomsky suggests is what separates human language from animal communication) offers evidence for the critical period hypothesis. Of course, Genie’s case is not so simple. Not only did she miss the critical period for learning language, she was also horrifically abused. She was malnourished and deprived of cognitive stimulation for most of her childhood. Researchers were also never able to fully determine if Genie suffered from pre-existing cognitive deficits. As an infant, a pediatrician had identified her as having some type of mental delay. So researchers were left to wonder whether Genie had suffered from cognitive deficits caused by her years of abuse or if she had been born with some degree of mental retardation.

Decision Regarding a Proposed Audit

Decision Regarding a Proposed Audit Decision Regarding a Proposed Audit I will not allow the proposal that our company contracts the brother of one of our partners as our firms auditor. In the contemporary business partnership environment, many irregularities are bound to occur with regard to financial profits disclosure. Hence, to prevent such incidents it would be important to uphold competent ethical perspectives. Auditors have been found to be capable of being exposed to potential threats on account of their independence when initiating an audit engagement (Houghton Campbell 226). In this case, the brotherly relationship of the auditor to one of our partners puts the whole exercise in jeopardy, since this auditor is capable of manipulating the results towards his favor. Moreover, a chartered accountant in practice shall be deemed guilty of professional misconduct under the Chartered Accountants Act, 1949, if he expresses his opinion on the financial statements of any enterprise in which he, his firm or a partner in his firm or any of his relatives h as a substantial interest (Gupta 480). I would recommend that in order to perform a proficient audit or financial assessment of the company, it would be critical to contract a competent and independent auditor. In this case, in as much as the suggestion shows competency, we are not sure of the credibility with regard to independence. This suggests that it will be important to perform an independence test before signing agreement to an auditing contract with a chosen auditor. According to the proposed CLERP 9 Bill, if the circumstances existThat: (a) impair, or might impair, the ability of the auditor, or professional member of the audit team, to exercise objective and impartial judgment in relation to conduct of an auditwould give a person with full knowledge of the facts and circumstances, reasonable grounds for concern (Houghton Campbell 229). Hence, by performing an independence test we will be able to establish any affiliations that can affect credibility on account of ethical standards.